To install Python binding from Pypi (binary), simply do: pip install keystone-engine In case you want to install from source code, follow the below steps. 0. Install the core engine as dependency Follow README.md in the root directory to compile & install the core. 1. To install pure Python binding on *nix, run the command below in the Python bindings directory: $ sudo make install To install Python3 binding package, run the command below: (Note: this requires python3 installed in your machine) $ sudo make install3 For example how to use Keystone API, see sample.py 2. To install Python binding on Windows: Run the following command in command prompt: C:\> C:\location_to_python\python.exe setup.py install Next, copy all the DLL files from the 'Core engine for Windows' package available on the same Keystone download page and paste it in the path: C:\location_to_python\Lib\site-packages\keystone\